教育经历

1981-1985：华东理工大学化学系，学士

1985-1988：华东理工大学化学系，硕士

1994-1997：日本大阪大学工学部应用化学系，博士

工作经历

1988-1993：华东理工大学专用化学品研究所，助教、讲师

1997-2001：日本大阪大学工学部应用化学系，助理教授

2001-2003：日本三菱化学株式会社横滨综合研究所，主任研究员

2003-至今：上海交通大学化学化工学院，教授

2009-至今：上海交通大学药学院，教授

2013-至今：上海交通大学，特聘教授

2017-至今：上海市手性药物分子工程重点实验室，主任

研究方向

1）有机合成及不对称催化

2）药物及其关键中间体的高效合成方法

科研项目

主持和参加国家自然科学基金重大、重点、重点国际合作和面上项目、国家“重大新药创制”科技重大专项、教育部优秀青年教师资助计划项目、上海市科委、经信委和教委重大和重点科技攻关项目以及与国内外多家企业的产学研合作项目等多项课题研究。有多项成果获得了工业化应用。“青蒿素的高效合成”入选2012年国内十大科技新闻和2012年上海市十大科技成果。

荣誉奖励

1）1993.10-1997.3日本政府奖学金

2）1995年中国专利局“中国专利十年成就展”银奖

3）2001年日本油脂工业会馆奖

4）2003年入选教育部“优秀青年教师资助计划”

5）2006年上海交通大学优秀教师一等奖（10名）

6）2008-2009年上海交通大学师德标兵（两年评一次5名）

7）2011年上海交通大学最受研究生欢迎的导师（10名）

8）2012年上海交通大学凯原十佳教师奖

9）2012年上海市育才奖

10）“青蒿素的高效合成”入选2012年国内十大科技新闻

11）“青蒿素的高效合成”入选2012年上海市十大科技成果

12）2013年上海交通大学特聘教授

13）2013年Thieme Chemistry Journal Award

14）2013年全国归侨侨眷先进个人

15）2013年上海市优秀博士学位论文指导教师

16）2014年上海市优秀学科带头人

17）2015年中国百篇最具影响国际学术论文

18）2015年上海市优秀博士学位论文指导教师

19）2016年获国务院政府特殊津贴

20）2016年上海领军人才

21）2016年上海交通大学第一届研究生"学术之星"导师（10名）

22）2017年RSC TOP1%高被引中国作者

23）2018年上海交通大学优秀博士学位论文指导教师（13名)

24）2018年上海交通大学教书育人奖集体奖二等奖（负责人）

25）2019年Osaka University Global Alumni Fellow

26）2019年上海市产学研合作优秀项目奖特等奖（第一完成人）

27）2019年上海交通大学教书育人奖二等奖 （个人）

28）2020年Japan Science Promotion Society (JSPS) Fellows

29）2020年RSC TOP1%高被引中国作者

30）2020年中国化学会会士

学术兼职

中国化学会高级会员

美国化学会会员

日本近畿化学协会会员

中国化学会有机化学委员会委员

中国化学会均相催化委员会委员

上海市化学化工学会有机化学委员会委员

上海市药学会药物化学委员会委员

国家自然科学基金委员会化学部会评专家

《中国医药工业杂志》副主编

《化学学报》编委

《有机化学》编委

《应用技术学报》编委

《Research on Chemical Intermediates》编委

Pharmaceutical Fronts（Chinese Journal of Pharmaceuticals B）编委

Chemistry—A European Journal编委

社会兼职

上海市侨联常委

上海交通大学侨联主席

教学工作

1）本科生：《有机化学》

2）本科生（致远学院）：《化学前沿》

3）研究生：《高等有机化学》，《近代合成方法》

代表性论文及专著

论文

Chong Liu, Jing Yuan, Zhenfeng Zhang*, Ilya D. Gridnev, and Wanbin Zhang*, "Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center", Angew. Chem. Int. Ed., 2021, accepted. VIP paper.

Muxing Zhou, Tatiana Gridneva, Zhenfeng Zhang, Ende He, Yangang Liu, and Wanbin Zhang*, "Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters", Angew. Chem. Int. Ed., 2021, 60, 1641-1645. VIP paper.

Dan Liu, Bowen Li, Jianzhong Chen, Ilya D. Gridnev, Deyue Yan and Wanbin Zhang*, "Ni-Catalyzed Asymmetric Hydrogenation of N-Aryl Imino Esters for the Efficient Synthesis of Chiral α-Aryl Glycines", Nat. Commun., 2020, 11, 5935.

Mo Wang,§ Lu Zhang,§ Xiaohong Huo,§ Zhenfeng Zhang,§ Qianjia Yuan, Panpan Li, Jianzhong Chen, Yashi Zou, Zhengxing Wu, and Wanbin Zhang*, "Catalytic Asymmetric Synthesis of the Anti-COVID-19 Drug Remdesivir", Angew. Chem. Int. Ed., 2020, accepted. VIP paper.

Rui He,§ Xiaohong Huo,§ Ling Zhao, Feijun Wang, Liyin Jiang, Jian Liao,* and Wanbin Zhang*, "Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates", J. Am. Chem. Soc., 2020, 142, in press.

Guanlin Li,§ Xiaohong Huo,§ Xieyang Jiang, and Wanbin Zhang*, "Asymmetric Synthesis of Allylic Compounds via Hydrofunctionalisation and Difunctionalisation of Dienes, Allenes, and Alkynes", Chem. Soc. Rev., 2020, 49, 2060-2118. Inside front cover

Yawen Hu, Jianzhong Chen, Bowen Li, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, "Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates", Angew. Chem. Int. Ed., 2020, 59, 5371-5375.

Liang Wu,§ Guoqiang Yang,§ and Wanbin Zhang*, "Ni-Catalyzed Enantioconvergent Coupling of Epoxides with Alkenylboronic Acids: Construction of Oxindoles Bearing Quaternary Carbons", CCS Chem., 2019, 1, 623-631.

Yanhua Hu, Zhenfeng Zhang, Jian Zhang, Yangang Liu, Ilya D. Gridnev, and Wanbin Zhang*, "Cobalt‐Catalyzed Asymmetric Hydrogenation of C=N Bond Enabled by Assisted Coordination and Non‐bonding Interaction", Angew. Chem. Int. Ed., 2019, 58, 15767-15771.

Jian Zhang, Jia Jia, Xincheng Zeng, Yuanhao Wang, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, "Chemo- and Enantioselective Hydrogenation of a-Formyl Enamides: An Efficient Access to Chiral α-Amido Aldehydes", Angew. Chem. Int. Ed., 2019, 58, 11505-11512, VIP paper.

Bowen Li, Jianzhong Chen, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, "Ni-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Imines", Angew. Chem. Int. Ed., 2019, 58, 7329-7334. VIP paper, Cover picture.

Jianzhong Chen, Zhenfeng Zhang, Bowen Li, Feilong Li, Yulin Wang, Min Zhao, Ilya D. Gridnev, Tsuneo Imamoto, and Wanbin Zhang*, "Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of Sterically Hindered N-Tosylimines", Nat. Commun., 2018, 9, 5000.

Xuezhen Kou, Qihang Shao, Chenghao Ye, Guoqiang Yang*, and Wanbin Zhang*, "Asymmetric Aza-Wacker-type Cyclization of N-Ts Hydrazine-Tethered Tetrasubstituted Olefins: Synthesis of Pyrazolines Bearing One Quaternary or Two Vicinal Stereocenters", J. Am. Chem. Soc., 2018, 140, 7587-7597.

Mao Quan, Xiaoxiao Wang, Liang Wu, Ilya D. Gridnev, Guoqiang Yang*, and Wanbin Zhang*, "Ni(II)-Catalyzed Asymmetric Alkenylations of Ketimines", Nat. Commun., 2018, 9, 2258.

Zhenfeng Zhang, Nicholas Andrew Butt, Muxing Zhou, Delong Liu, and Wanbin Zhang*, "Asymmetric Transfer and Pressure Hydrogenation with Earth-Abundant Transition Metal Catalysts", Chin. J. Chem., 2018, 36, 443-454. Invited Review

Xiaohong Huo, Jiacheng Zhang, Jingke Fu, Rui He, and Wanbin Zhang*, "Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters", J. Am. Chem. Soc., 2018, 140, 2080-2084.

Guoqiang Yang and Wanbin Zhang*, "Renaissance of Pyridine-Oxazolines as Chiral Ligands for Asymmetric Catalysis", Chem. Soc. Rev., 2018, 47, 1783-1810. Cover Review

Xiaohong Huo, Rui He, Jingke Fu, Jiacheng Zhang, Guoqiang Yang, and Wanbin Zhang*, "Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis", J. Am. Chem. Soc., 2017, 139, 9819-9822.

Xiaohong Huo,§ Rui He,§ Xiao Zhang, and Wanbin Zhang*, "An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones", J. Am. Chem. Soc., 2016, 138, 11093-11096.

Zhenfeng Zhang,§ Nicholas Butt,§ and Wanbin Zhang*, "Asymmetric Hydrogenation of Non-Aromatic Cyclic Substrates", Chem. Rev., 2016, 116, 14769-14827.

Jianzhong Chen, Zhenfeng Zhang, Delong Liu, and Wanbin Zhang*, "Palladium-Catalyzed Chemo- and Enantioselective C-O Bond Cleavage of α-Acyloxy Ketones via Hydrogenolysis", Angew. Chem. Int. Ed., 2016, 55, 8444-8447.

Nicholas Butt and Wanbin Zhang*, " Transition Metal-catalyzed Allylic Substitution Reactions with Unactivated Allylic Substrates ", Chem. Soc. Rev., 2015, 44, 7929-7967. Cover Review

Qiupeng Hu, Zhenfeng Zhang, Yangang Liu, Tsuneo Imamoto, and Wanbin Zhang*, "ZnCl2-Promoted Asymmetric Hydrogenation of β-Secondary-Amino Ketones Catalyzed by a P-Chiral Bisphosphine-Rh Complex", Angew. Chem. Int. Ed., 2015, 54, 2260-2264.

Xun-Xiang Guo*, Da-Wei Gu, Zhengxing Wu, and Wanbin Zhang*, "Copper-Catalyzed C-H Functionalization Reactions: Efficient Synthesis of Heterocycles", Chem. Rev., 2015, 115, 1622-1651.

Xiaohong Huo, Guoqiang Yang, Delong Liu, Yangang Liu, Ilya D. Gridnev*, and Wanbin Zhang*, "Palladium-Catalyzed Allylic Alkylation of Simple Ketones with Allylic Alcohols and Its Mechanistic Study", Angew. Chem. Int. Ed., 2014, 53, 6776-6780.

Yuanyuan Liu, Ilya D. Gridnev*, and Wanbin Zhang*, "Mechanism of Asymmetric Hydrogenation of Functionalized Olefins with Ir/iPr-BiphPHOX Catalyst: NMR and DFT Study", Angew. Chem. Int. Ed., 2014, 53, 1901-1905.

Jianzhong Chen, Delong Liu, Nicholas Butt, Chao Li, Dongyang Fan, Yangang Liu, and Wanbin Zhang*, "Palladium-Catalyzed Asymmetric Hydrogenation of a-Acyloxy-1-aryletheanones", Angew. Chem. Int. Ed., 2013, 52, 11632-11636.

Guoqiang Yang, Wanbin Zhang*, "A Palladium-Catalyzed Enantioselective Addition of Arylboronic Acids to Cyclic Ketimines", Angew. Chem. Int. Ed., 2013, 52, 7540-7544.

Yuanyuan Liu, Wanbin Zhang*, "Ir-Catalyzed Asymmetric Hydrogenation of a-Alkylidene Succinimides", Angew. Chem. Int. Ed., 2013, 52, 2203-2206.

Guoqiang Yang, Chaoren Shen, Wanbin Zhang*, "An Asymmetric Aerobic Aza-Wacker-Type Cyclization: Synthesis of Isoindolinones Bearing Tetrasubstituted Carbon Stereocenters", Angew. Chem. Int. Ed., 2012, 51, 9141-9145.

Xiaohu Zhao,§ Delong Liu,§ Hui Guo, Yangang Liu, Wanbin Zhang*, "C-N Bond Cleavage of Allylic Amines via Hydrogen Bond Activation with Alcohol Solvents in Pd-Catalyzed Allylic Alkylation of Carbonyl Compounds",  J. Am. Chem. Soc., 2011, 133, 19354-19357.

Zhenfeng Zhang, Fang Xie, Jia Jia, Wanbin Zhang*, “Chiral Bicycle Imidazole Nucleophilic Catalysts: Rational Design, Facile Synthesis, and Successful Application in Asymmetric Steglich Rearrangement”, J. Am. Chem. Soc., 2010, 132, 15939-15941.